Simple, Accurate and rapid HPLC methods for paroxetine hydrochloride tablets and determination of drug release in modified dosage form were developed. USP type-II, paddle apparatus was selected to determine the % drug release. 0.1 N HCl, 6.8 pH phosphate buffer and 7.4 pH Phosphate buffer were used as dissolution media. Column eluent was detected at 295 nm. Methods were validated according to the present ICH guidelines for linearity, accuracy, precision, LOD, LOQ, robustness and results were found satisfactory. Method shows linearity in the range of 0.4-1.2 µg/ml (0.1 N HCl), 2-10 µg/ml (6.8 pH phosphate buffer) and 0.2-1 µg/ml (7.4 pH phosphate buffer) with correlation coefficient 0.9980, 0.9968 and 0.9983 respectively. Accuracy was found in the range of 98.42%-101.25% (0.1 N HCl), 98.85%-100.09% (6.8 pH phosphate buffer) and 98.84%-101.06% (7.4 pH phosphate buffer). LOD and LOQ were found to be 0.772 µg/ml and 1.0906 µg/ml (0.1 N HCl), 2.274 µg/ml and 6.80 µg/ml (6.8 pH phosphate buffer), 0.738 µg/ml and 0.923 µg/ml (7.4 pH phosphate buffer). %Assay was found to be 93.87% (0.1 N HCl), 97.78% (6.8 pH phosphate buffer) and 96.27% (7.4 pH phosphate buffer). The dissolution profile of marketed brands of controlled release paroxetine hydrochloride tablets were compared with reference brand. The results were subjected to statistical evaluation of similarity factor and difference factor. There was no significant difference found between dissolution profiles of different brands of paroxetine hydrochloride controlled release tablets. Comparison study shows that there was similarity in dissolution profile of all brands.
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